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Jacksonville Jaguars v Buffalo Bills

Source: Brett Carlsen / Getty

Freshman quarterback Caylin Newton, the younger brother of quarterback Cam Newton, helped the Howard Bisons pull off the largest point spread upset in college history. The Bisons beat the Rebels 43-40 in Vegas. Caylin threw for 140 yards and a touchdown, and lead the Bisons to the game-winning score with 7:34 still to go in the game.

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